Modulation of Cortical Oscillations by Low-Frequency Direct Cortical Stimulation Is State-Dependent.

ABSTRACT: Cortical oscillations play a fundamental role in organizing large-scale functional brain networks. Noninvasive brain stimulation with temporally patterned waveforms such as repetitive transcranial magnetic stimulation (rTMS) and transcranial alternating current stimulation (tACS) have been proposed to modulate these oscillations. Thus, these stimulation modalities represent promising new approaches for the treatment of psychiatric illnesses in which these oscillations are impaired. However, the mechanism by which periodic brain stimulation alters endogenous oscillation dynamics is debated and appears to depend on brain state. Here, we demonstrate with a static model and a neural oscillator model that recurrent excitation in the thalamo-cortical circuit, together with recruitment of cortico

SUBMITTER: Alagapan S 

PROVIDER: S-EPMC4811434 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature