TLR3 Agonist Poly-IC Induces IL-33 and Promotes Myelin Repair.

ABSTRACT:

Background

Impaired remyelination of demyelinated axons is a major cause of neurological disability. In inflammatory demyelinating disease of the central nervous system (CNS), although remyelination does happen, it is often incomplete, resulting in poor clinical recovery. Poly-IC a known TLR3 agonist and IL-33, a cytokine which is induced by poly-IC are known to influence recovery and promote repair in experimental models of CNS demyelination.

Methodology and principal findings

We examined the effect of addition of poly-IC and IL-33 on the differentiation and maturation of oligodendrocyte precursor cells (OPC) cultured in vitro. Both Poly-IC and IL-33 induced transcription of myelin genes and the differentiation of OPC to mature myelin forming cells. Poly-IC induced IL-33 in

SUBMITTER: Natarajan C 

PROVIDER: S-EPMC4811556 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature