Baculovirus Displaying Hemagglutinin Elicits Broad Cross-Protection against Influenza in Mice.

ABSTRACT: The widespread influenza virus infection further emphasizes the need for novel vaccine strategies that effectively reduce the impact of epidemic as well as pandemic influenza. Conventional influenza vaccines generally induce virus neutralizing antibody responses which are specific for a few antigenically related strains within the same subtype. However, antibodies directed against the conserved stalk domain of HA could neutralize multiple subtypes of influenza virus and thus provide broad-spectrum protection. In this study, we designed and constructed a recombinant baculovirus-based vaccine, rBac-HA virus, that expresses full-length HA of pandemic H1N1 influenza virus (A/California/04/09) on the viral envelope. We demonstrated that repeated intranasal immunizations with rBac-HA virus induc

SUBMITTER: Sim SH 

PROVIDER: S-EPMC4811570 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature