Effects of Arterial Stiffness on Brain Integrity in Young Adults From the Framingham Heart Study.

ABSTRACT:

Background and purpose

Previous work from the Framingham Heart Study suggests that brain changes because of arterial aging may begin in young adulthood and that such changes precede cognitive deficits. The objective of this study was to determine the association of arterial stiffness with measures of white matter and gray matter (GM) integrity in young adults.

Methods

One thousand nine hundred three participants from the Framingham Heart Study Third Generation (mean age, 46±8.7 years) had complete tonometry measurements and brain magnetic resonance imaging (T1-weighted and diffusion tensor imaging). Tonometry measures included carotid-femoral pulse wave velocity, augmentation index, carotid-brachial pressure amplification, and central pulse pressure. Fractional anisotropy an

SUBMITTER: Maillard P 

PROVIDER: S-EPMC4811686 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature