Patient Characteristics and Outcomes in Adolescents and Young Adults (AYA) With Acute Myeloid Leukemia (AML).

ABSTRACT:

Background

Little is known about outcomes of acute myeloid leukemia (AML) in adolescents and young adults (AYA). The purpose of this study is to determine the characteristics and outcomes of AYA AML patients in comparison to older adult patients with AML.

Patients and methods

We retrospectively analyzed all AML patients treated at our institution from 1965 to 2009 who were aged 16 to 29 years.

Results

Among 3922 adult AML patients treated during this period, 432 (11%) were identified as AYA. Median age was 23 years (range, 16-29 years); 73 (17%) patients had core binding factor (CBF)-AML [inversion (16), translocation (8:21)], and 51 (12%) had acute promyelocytic leukemia. Complete remission (CR) rates were 93% for CBF AML, 78% for APL, 77% with diploid karyotype, and

SUBMITTER: Pemmaraju N 

PROVIDER: S-EPMC4811701 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature