Developmental Profile of Ion Channel Specializations in the Avian Nucleus Magnocellularis.

ABSTRACT: Ultrafast and temporally precise action potentials (APs) are biophysical specializations of auditory brainstem neurons; properties necessary for encoding sound localization and communication cues. Fundamental to these specializations are voltage dependent potassium (KV) and sodium (NaV) ion channels. Here, we characterized the functional development of these ion channels and quantified how they shape AP properties in the avian cochlear nucleus magnocellularis (NM). We report that late developing NM neurons (embryonic [E] days 19-21) generate fast APs that reliably phase lock to sinusoidal inputs at 75 Hz. In contrast, early developing neurons (

SUBMITTER: Hong H 

PROVIDER: S-EPMC4811932 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature