Essential role of UCP1 modulating the central effects of thyroid hormones on energy balance.

ABSTRACT:

Objective

Classically, metabolic effects of thyroid hormones (THs) have been considered to be peripherally mediated, i.e. different tissues in the body respond directly to thyroid hormones with an increased metabolism. An alternative view is that the metabolic effects are centrally regulated. We have examined here the degree to which prolonged, centrally infused triiodothyronine (T3) could in itself induce total body metabolic effects and the degree to which brown adipose tissue (BAT) thermogenesis was essential for such effects, by examining uncoupling protein 1 (UCP1) KO mice.

Methods

Wildtype and UPC1 KO mice were centrally-treated with T3 by using minipumps. Metabolic measurements were analyzed by indirect calorimetry and expression analysis by RT-PCR or western blot. BA

SUBMITTER: Alvarez-Crespo M 

PROVIDER: S-EPMC4812006 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature