Establishment of Relational Model of Congenital Heart Disease Markers and GO Functional Analysis of the Association between Its Serum Markers and Susceptibility Genes.

ABSTRACT:

Purpose

The purpose of present study was to construct the best screening model of congenital heart disease serum markers and to provide reference for further prevention and treatment of the disease.

Methods

Documents from 2006 to 2014 were collected and meta-analysis was used for screening susceptibility genes and serum markers closely related to the diagnosis of congenital heart disease. Data of serum markers were extracted from 80 congenital heart disease patients and 80 healthy controls, respectively, and then logistic regression analysis and support vector machine were utilized to establish prediction models of serum markers and Gene Ontology (GO) functional annotation.

Results

Results showed that NKX2.5, GATA4, and FOG2 were susceptibility genes of congenital hea

SUBMITTER: Liu M 

PROVIDER: S-EPMC4812235 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature