Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium.

ABSTRACT: Individual signaling pathways operate in the context of the broader signaling network. Thus, the response of a cell to signals from the environment is affected by the state of the signaling network, such as the clinically relevant example of whether some components in the network are inhibited. The cytokine tumor necrosis factor-α (TNF-α) promotes opposing cellular behaviors under different conditions; the outcome is influenced by the state of the network. For example, in the mouse intestinal epithelium, inhibition of the mitogen-activated protein kinase (MAPK) kinase MEK alters the timing of TNF-α-induced apoptosis. We investigated whether MAPK signaling directly influences TNF-α-induced apoptosis or whether network-level effects secondary to inhibition of the MAPK pathway alter the cellu

SUBMITTER: Gierut JJ 

PROVIDER: S-EPMC4812576 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature