Topologically associated domains enriched for lineage-specific genes reveal expression-dependent nuclear topologies during myogenesis.

ABSTRACT: The linear distribution of genes across chromosomes and the spatial localization of genes within the nucleus are related to their transcriptional regulation. The mechanistic consequences of linear gene order, and how it may relate to the functional output of genome organization, remain to be fully resolved, however. Here we tested the relationship between linear and 3D organization of gene regulation during myogenesis. Our analysis has identified a subset of topologically associated domains (TADs) that are significantly enriched for muscle-specific genes. These lineage-enriched TADs demonstrate an expression-dependent pattern of nuclear organization that influences the positioning of adjacent nonenriched TADs. Therefore, lineage-enriched TADs inform cell-specific genome organization during

SUBMITTER: Neems DS 

PROVIDER: S-EPMC4812766 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature