Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology.

ABSTRACT: Deregulation of the cholesterol pathway is an anomaly observed in human diseases, many of which have in common neurological involvement and unknown pathogenesis. In this study we have used Mevalonate Kinase Deficiency (MKD) as a disease-model in order to investigate the link between the deregulation of the mevalonate pathway and the consequent neurodegeneration. The blocking of the mevalonate pathway in a neuronal cell line (Daoy), using statins or mevalonate, induced an increase in the expression of the inflammasome gene (NLRP3) and programmed cell death related to mitochondrial dysfunction. The morphology of the mitochondria changed, clearly showing the damage induced by oxidative stress and the decreased membrane potential associated with the alterations of the mitochondrial function. T

SUBMITTER: Marcuzzi A 

PROVIDER: S-EPMC4813225 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature