On-the-Road Driving Performance the Morning after Bedtime Use of Suvorexant 20 and 40 mg: A Study in Non-Elderly Healthy Volunteers.

ABSTRACT:

Study objective

To evaluate next-morning driving performance in adults younger than 65 years, after single and repeated doses of suvorexant 20 and 40 mg.

Design

Double-blind, placebo-controlled, 4-period crossover study.

Setting

Maastricht University, The Netherlands.

Participants

28 healthy volunteers (15 females), aged 23 to 64 years.

Interventions

Suvorexant (20 and 40 mg) for 8 consecutive nights; zopiclone 7.5 mg nightly on day 1 and 8; placebo.

Measurements

Performance on day 2 and 9 (9 h after dosing) using a one-hour standardized highway driving test in normal traffic, measuring standard deviation of lateral position (SDLP). Drug-placebo changes in SDLP > 2.4 cm were considered to reflect meaningful driving impairment.

Results

Mean

SUBMITTER: Vermeeren A 

PROVIDER: S-EPMC4813357 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature