Assessment of Recombination in the S-segment Genome of Crimean-Congo Hemorrhagic Fever Virus in Iran.

ABSTRACT:

Background

Crimean-Congo Hemorrhagic Fever Virus (CCHFV) belongs to genus Nairovirus and family Bunyaviridae. The main aim of this study was to investigate the extent of recombination in S-segment genome of CCHFV in Iran.

Methods

Samples were isolated from Iranian patients and those available in GenBank, and analyzed by phylogenetic and bootscan methods.

Results

Through comparison of the phylogenetic trees based on full length sequences and partial fragments in the S-segment genome of CCHFV, genetic switch was evident, due to recombination event. Moreover, evidence of multiple recombination events was detected in query isolates when bootscan analysis was used by SimPlot software.

Conclusion

Switch of different genomic regions between different strains by recomb

SUBMITTER: Chinikar S 

PROVIDER: S-EPMC4813403 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature