Monitoring Cellular Phosphorylation Signaling Pathways into Chromatin and Down to the Gene Level.

ABSTRACT: Protein phosphorylation, one of the most common and important modifications of acute and reversible regulation of protein function, plays a dominant role in almost all cellular processes. These signaling events regulate cellular responses, including proliferation, differentiation, metabolism, survival, and apoptosis. Several studies have been successfully used to identify phosphorylated proteins and dynamic changes in phosphorylation status after stimulation. Nevertheless, it is still rather difficult to elucidate precise complex phosphorylation signaling pathways. In particular, how signal transduction pathways directly communicate from the outer cell surface through cytoplasmic space and then directly into chromatin networks to change the transcriptional and epigenetic landscape remains

SUBMITTER: Han Y 

PROVIDER: S-EPMC4813704 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature