A Quantitative Proteomic Analysis of In Vitro Assembled Chromatin.

ABSTRACT: The structure of chromatin is critical for many aspects of cellular physiology and is considered to be the primary medium to store epigenetic information. It is defined by the histone molecules that constitute the nucleosome, the positioning of the nucleosomes along the DNA and the non-histone proteins that associate with it. These factors help to establish and maintain a largely DNA sequence-independent but surprisingly stable structure. Chromatin is extensively disassembled and reassembled during DNA replication, repair, recombination or transcription in order to allow the necessary factors to gain access to their substrate. Despite such constant interference with chromatin structure, the epigenetic information is generally well maintained. Surprisingly, the mechanisms that coordinate ch

SUBMITTER: Volker-Albert MC 

PROVIDER: S-EPMC4813712 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature