Comparative Proteomics Identifies Host Immune System Proteins Affected by Infection with Mycobacterium bovis.

ABSTRACT: Mycobacteria of the Mycobacterium tuberculosis complex (MTBC) greatly impact human and animal health worldwide. The mycobacterial life cycle is complex, and the mechanisms resulting in pathogen infection and survival in host cells are not fully understood. Eurasian wild boar (Sus scrofa) are natural reservoir hosts for MTBC and a model for mycobacterial infection and tuberculosis (TB). In the wild boar TB model, mycobacterial infection affects the expression of innate and adaptive immune response genes in mandibular lymph nodes and oropharyngeal tonsils, and biomarkers have been proposed as correlates with resistance to natural infection. However, the mechanisms used by mycobacteria to manipulate host immune response are not fully characterized. Our hypothesis is that the immune system pro

SUBMITTER: Lopez V 

PROVIDER: S-EPMC4814110 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature