Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments.

ABSTRACT:

Objective

To identify disease relevant genes and pathways associated with knee Osteoarthritis (OA) progression in human subjects using medial and lateral compartment dominant OA knee tissue.

Design

Gene expression of knee cartilage was comprehensively assessed for three regions of interest from human medial dominant OA (n = 10) and non-OA (n = 6) specimens. Histology and gene expression were compared for the regions with minimal degeneration, moderate degeneration and significant degeneration. Agilent whole-genome microarray was performed and data were analyzed using Agilent GeneSpring GX11.5. Significant differentially regulated genes were further investigated by Ingenuity Pathway Analysis (IPA) to identify functional categories. To confirm their association with disease se

SUBMITTER: Chou CH 

PROVIDER: S-EPMC4814163 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature