Essential Role of X-Box Binding Protein-1 during Endoplasmic Reticulum Stress in Podocytes.

ABSTRACT: Podocytes are terminally differentiated epithelial cells that reside along the glomerular filtration barrier. Evidence suggests that after podocyte injury, endoplasmic reticulum stress response is activated, but the molecular mechanisms involved are incompletely defined. In a mouse model, we confirmed that podocyte injury induces endoplasmic reticulum stress response and upregulated unfolded protein response pathways, which have been shown to mitigate damage by preventing the accumulation of misfolded proteins in the endoplasmic reticulum. Furthermore, simultaneous podocyte-specific genetic inactivation of X-box binding protein-1 (Xbp1), a transcription factor activated during endoplasmic reticulum stress and critically involved in the untranslated protein response, and Sec63, a heat shock

SUBMITTER: Hassan H 

PROVIDER: S-EPMC4814187 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature