Reliability and reproducibility of individual differences in functional connectivity acquired during task and resting state.

ABSTRACT:

Objectives

Application of fMRI connectivity metrics as diagnostic biomarkers at the individual level will require reliability, sensitivity and specificity to longitudinal changes in development, aging, neurocognitive, and behavioral performance and pathologies. Such metrics have not been well characterized for recent advances in BOLD acquisition.

Experimental design

Analysis of multiband BOLD data from the HCP 500 Subjects Release was performed with FIX ICA and with WM, CSF and motion parameter regression. Analysis with ROIs covering the gray matter at 5 mm resolution was performed to assess functional connectivity. ROIs in key areas were used to demonstrate statistical differences between specific connections. Reproducibility of group-mean functional connectivity and for si

SUBMITTER: Shah LM 

PROVIDER: S-EPMC4814225 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature