An integrated network platform for contextual prioritization of drugs and pathways.

ABSTRACT: Repurposing of drugs to novel disease indications has promise for faster clinical translation. However, identifying the best drugs for a given pathological context is not trivial. We developed an integrated random walk-based network framework that combines functional biomolecular relationships and known drug-target interactions as a platform for contextual prioritization of drugs, genes and pathways. We show that the use of gene-centric or drug-centric data, such as gene expression data or a phenotypic drug screen, respectively, within this network platform can effectively prioritize drugs and pathways, respectively, to the studied biological context. We demonstrate that various genomic data can be used as contextual cues to effectively prioritize drugs to the studied context, while simila

SUBMITTER: Segura-Cabrera A 

PROVIDER: S-EPMC4814269 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature