Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study.

ABSTRACT:

Background

Lithium is a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identified.

Methods

Here, we report the results of a genome-wide association study of lithium response in 2563 patients collected by 22 participating sites from the International Consortium on Lithium Genetics (ConLiGen). Data from common single nucleotide polymorphisms (SNPs) were tested for association with categorical and continuous ratings of lithium response. Lithium response was measured using a well established scale (Alda scale). Genotyped SNPs were used to generate data at more than 6 million sites, using standard geno

SUBMITTER: Hou L 

PROVIDER: S-EPMC4814312 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature