Brain imaging demonstrates a reduced neural impact of eating in obesity.

ABSTRACT:

Objective

This study investigated functional brain response differences to food in women with BMI either <25 kg/m(2) (lean) or >35 kg/m(2) (severe obesity).

Design and methods

Thirty women, 18-65 years old, from academic medical centers participated. Baseline brain perfusion was measured with arterial spin labeling. Brain activity was measured via blood-oxygen-level-dependent functional magnetic resonance imaging in response to food cues, and appeal to cues was rated. Subjective hunger/fullness was reported pre- and post-imaging. After a standard meal, measures were repeated.

Results

When fasting, brain perfusion did not differ significantly between groups; and both groups showed significantly increased activity in the neo- and limbic cortices and midbrain compared wi

SUBMITTER: Puzziferri N 

PROVIDER: S-EPMC4814322 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature