Bioluminescence Tomography-Guided Radiation Therapy for Preclinical Research.

ABSTRACT:

Purpose

In preclinical radiation research, it is challenging to localize soft tissue targets based on cone beam computed tomography (CBCT) guidance. As a more effective method to localize soft tissue targets, we developed an online bioluminescence tomography (BLT) system for small-animal radiation research platform (SARRP). We demonstrated BLT-guided radiation therapy and validated targeting accuracy based on a newly developed reconstruction algorithm.

Methods and materials

The BLT system was designed to dock with the SARRP for image acquisition and to be detached before radiation delivery. A 3-mirror system was devised to reflect the bioluminescence emitted from the subject to a stationary charge-coupled device (CCD) camera. Multispectral BLT and the incomplete variables tr

SUBMITTER: Zhang B 

PROVIDER: S-EPMC4814325 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature