Lewis acid-promoted [2 + 2] cycloadditions of alkenes with aryl ketenes.

ABSTRACT: A method for the [2 + 2] cycloaddition of aryl ketenes and alkenes is presented. The process involves the in situ generation of a ketene in the presence of a Lewis acid. The utility of products is demonstrated towards the synthesis of a common scaffold found in several natural product families.

SUBMITTER: Rigsbee EM 

PROVIDER: S-EPMC4814371 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature