Dysregulated 14-3-3 Family in Peripheral Blood Leukocytes of Patients with Schizophrenia.

ABSTRACT: The 14-3-3 family, which is composed of seven distinct members in humans, plays important roles in the cell cycle, apoptosis, synaptic plasticity and neuronal differentiation and migration. Previous genetic and post-mortem gene expression studies have linked this family to schizophrenia. However, the direction of gene expression changes in these studies has been inconsistent, and reports of 14-3-3 gene expression in living schizophrenic patients are still lacking. Here, we assessed 14-3-3 gene and protein expression levels in peripheral blood leukocytes from drug-naïve first-episode schizophrenic patients and matched controls. mRNA and protein expression levels were quantified by qRT-PCR and UPLC-MRM/MS, respectively. Expression analysis revealed four downregulated and one upregulated mRNA

SUBMITTER: Qing Y 

PROVIDER: S-EPMC4814835 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature