Prioritization of anticancer drugs against a cancer using genomic features of cancer cells: A step towards personalized medicine.

ABSTRACT: In this study, we investigated drug profile of 24 anticancer drugs tested against a large number of cell lines in order to understand the relation between drug resistance and altered genomic features of a cancer cell line. We detected frequent mutations, high expression and high copy number variations of certain genes in both drug resistant cell lines and sensitive cell lines. It was observed that a few drugs, like Panobinostat, are effective against almost all types of cell lines, whereas certain drugs are effective against only a limited type of cell lines. Tissue-specific preference of drugs was also seen where a drug is more effective against cell lines belonging to a specific tissue. Genomic features based models have been developed for each anticancer drug and achieved average correl

SUBMITTER: Gupta S 

PROVIDER: S-EPMC4814902 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature