An evolutionary roadmap to the microtubule-associated protein MAP Tau.

ABSTRACT:

Background

The microtubule associated protein Tau (MAPT) promotes assembly and interaction of microtubules with the cytoskeleton, impinging on axonal transport and synaptic plasticity. Its neuronal expression and intrinsic disorder implicate it in some 30 tauopathies such as Alzheimer's disease and frontotemporal dementia. These pathophysiological studies have yet to be complemented by computational analyses of its molecular evolution and structural models of all its functional domains to explain the molecular basis for its conservation profile, its site-specific interactions and the propensity to conformational disorder and aggregate formation.

Results

We systematically annotated public sequence data to reconstruct unspliced MAPT, MAP2 and MAP4 transcripts spanning all repr

SUBMITTER: Sundermann F 

PROVIDER: S-EPMC4815063 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature