Topology based identification and comprehensive classification of four-transmembrane helix containing proteins (4TMs) in the human genome.

ABSTRACT:

Background

Membrane proteins are key components in a large spectrum of diverse functions and thus account for the major proportion of the drug-targeted portion of the genome. From a structural perspective, the α-helical transmembrane proteins can be categorized into major groups based on the number of transmembrane helices and these groups are often associated with specific functions. When compared to the well-characterized seven-transmembrane containing proteins (7TM), other TM groups are less explored and in particular the 4TM group. In this study, we identify the complete 4TM complement from the latest release of the human genome and assess the 4TM structure group as a whole. We functionally characterize this dataset and evaluate the resulting groups and ubiquitous functions, an

SUBMITTER: Attwood MM 

PROVIDER: S-EPMC4815072 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature