A Novel Typing Method for Streptococcus pneumoniae Using Selected Surface Proteins.

ABSTRACT: The diverse pneumococcal diseases are associated with different pneumococcal lineages, or clonal complexes. Nevertheless, intra-clonal genomic variability, which influences pathogenicity, has been reported for surface virulence factors. These factors constitute the communication interface between the pathogen and its host and their corresponding genes are subjected to strong selective pressures affecting functionality and immunogenicity. First, the presence and allelic dispersion of 97 outer protein families were screened in 19 complete pneumococcal genomes. Seventeen families were deemed variable and were then examined in 216 draft genomes. This procedure allowed the generation of binary vectors with 17 positions and the classification of strains into surfotypes. They represent the outer

SUBMITTER: Domenech A 

PROVIDER: S-EPMC4815138 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature