Repeatable Population Dynamics among Vesicular Stomatitis Virus Lineages Evolved under High Co-infection.

ABSTRACT: Parasites and hosts can experience oscillatory cycles, where the densities of these interacting species dynamically fluctuate through time. Viruses with different replication strategies can also interact to produce cyclical dynamics. Frequent cellular co-infection can select for defective-interfering particles (DIPs): "cheater" viruses with shortened genomes that interfere with intracellular replication of full-length (ordinary) viruses. DIPs are positively selected when rare because they out-replicate ordinary viruses during co-infection, but DIPs are negatively selected when common because ordinary viruses become unavailable for intracellular exploitation via cheating. Here, we tested whether oscillatory dynamics of ordinary viruses were similar across independently evolved populations o

SUBMITTER: Williams ES 

PROVIDER: S-EPMC4815288 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature