Meta-analysis and meta-regression of transcriptomic responses to water stress in Arabidopsis.

ABSTRACT: The large amounts of transcriptome data available for Arabidopsis thaliana make a compelling case for the need to generalize results across studies and extract the most robust and meaningful information possible from them. The results of various studies seeking to identify water stress-responsive genes only partially overlap. The aim of this work was to combine transcriptomic studies in a systematic way that identifies commonalities in response, taking into account variation among studies due to batch effects as well as sampling variation, while also identifying the effect of study-specific variables, such as the method of applying water stress, and the part of the plant the mRNA was extracted from. We used meta-analysis, the quantitative synthesis of independent research results, to summa

SUBMITTER: Rest JS 

PROVIDER: S-EPMC4815425 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature