Heterogeneity in recent-onset type 1 diabetes - a clinical trial perspective.

ABSTRACT:

Background

Type 1 diabetes (T1D) TrialNet is a National Institutes of Health-sponsored clinical trial network aimed at altering the disease course of T1D. The purpose of this study is to evaluate age-dependent heterogeneity in clinical, metabolic and immunologic characteristics of individuals with recent-onset T1D, to identify cohorts of interest and to aid in planning of future studies.

Methods

Eight hundred eighty-three individuals with recent-onset T1D involved in five TrialNet studies were categorized by age as follows: ≥18 years, 12-17 years, 8-12 years and <8 years. Data were compared with healthy age-matched subjects in the National Health and Nutrition Examination Survey.

Results

Only 2.0% of the individuals overall were excluded from trial participation becau

SUBMITTER: Bollyky JB 

PROVIDER: S-EPMC4815427 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature