S100B Serum Levels Predict Treatment Response in Patients with Melancholic Depression.

ABSTRACT:

Background

There is an ongoing search for biomarkers in psychiatry, for example, as diagnostic tools or predictors of treatment response. The neurotrophic factor S100 calcium binding protein B (S100B) has been discussed as a possible predictor of antidepressant response in patients with major depression, but also as a possible biomarker of an acute depressive state. The aim of the present study was to study the association of serum S100B levels with antidepressant treatment response and depression severity in melancholically depressed inpatients.

Methods

After a wash-out period of 1 week, 40 inpatients with melancholic depression were treated with either venlafaxine or imipramine. S100B levels and Hamilton Depression Rating Scale (HAM-D) scores were assessed at baseline, aft

SUBMITTER: Ambree O 

PROVIDER: S-EPMC4815471 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature