UGMDR: a unified conceptual framework for detection of multifactor interactions underlying complex traits.

ABSTRACT: Biological outcomes are governed by multiple genetic and environmental factors that act in concert. Determining multifactor interactions is the primary topic of interest in recent genetics studies but presents enormous statistical and mathematical challenges. The computationally efficient multifactor dimensionality reduction (MDR) approach has emerged as a promising tool for meeting these challenges. On the other hand, complex traits are expressed in various forms and have different data generation mechanisms that cannot be appropriately modeled by a dichotomous model; the subjects in a study may be recruited according to its own analytical goals, research strategies and resources available, not only consisting of homogeneous unrelated individuals. Although several modifications and extens

SUBMITTER: Lou XY 

PROVIDER: S-EPMC4815578 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature