Common variants in TGFBR2 and miR-518 genes are associated with hypertension in the Chinese population.

ABSTRACT:

Background

An animal study reported that TGF-β1 maturation was linked to the homeostasis of blood pressure and elastogenesis of essential hypertension (EH). Recent advances require further research of TGF-β1 receptor in EH.

Methods

A case-control study comprised of 2,012 adult hypertension case patients and 2,210 adult control subjects was conducted, and the association with blood pressure was further tested in children. Logistic regression and calculated genetic risk score were used to evaluate the effects of one single nucleotide polymorphism (SNP) and multiple SNPs on EH, respectively.

Results

The genetic risk score of 10 SNPs showed a significant association with hypertension; the odds ratio of the upper quartile vs. the lower quartile was 1.282 (P = 4.67 × 10(-3)

SUBMITTER: Chen J 

PROVIDER: S-EPMC4815702 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature