Effects of a lifestyle intervention on endothelial function in men on long-term androgen deprivation therapy for prostate cancer.

ABSTRACT:

Background

Treatment of prostate cancer with androgen deprivation therapy (ADT) is associated with metabolic changes that have been linked to an increase in cardiovascular risk.

Methods

This randomised controlled trial investigated the effects of a 12-week lifestyle intervention that included supervised exercise training and dietary advice on markers of cardiovascular risk in 50 men on long-term ADT recruited to an on-going study investigating the effects of such a lifestyle intervention on quality of life. Participants were randomly allocated to receive the intervention or usual care. Cardiovascular outcomes included endothelial function (flow-mediated dilatation (FMD) of the brachial artery), blood pressure, body composition and serum lipids. Additional outcomes included t

SUBMITTER: Gilbert SE 

PROVIDER: S-EPMC4815775 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature