Survivin and XIAP: two valuable biomarkers in medullary thyroid carcinoma.

ABSTRACT:

Background

Medullary thyroid carcinoma (MTC) accounts for ∼5% of all thyroid malignancies. To date, surgery is the first-line therapy with curative intention. However, for advanced MTC, conventional chemotherapeutic agents do not provide convincing results. Therefore, the identification of biomarkers that can be antagonised by small-molecule therapeutics may lead to novel encouraging treatment options.

Methods

Seventy-nine patients with surgically resected and histologically confirmed MTC were included in this study. Tissue microarrays were constructed to assess the relationship between inhibitor of apoptosis proteins (IAPs) survivin or XIAP expression levels and clinicopathological variables as well as overall survival.

Results

High survivin or XIAP expression was as

SUBMITTER: Werner TA 

PROVIDER: S-EPMC4815780 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature