Serum lactate dehydrogenase and survival following cancer diagnosis.

ABSTRACT:

Background

There is evidence that high level of serum lactate dehydrogenase (LDH) is associated with poorer overall survival in several malignancies, but its link to cancer-specific survival is unclear.

Methods

A total of 7895 individuals diagnosed with cancer between 1986 and 1999 were selected for this study. Multivariable Cox proportional hazards regression was used to assess overall and cancer-specific death by the z-score and clinical categories of serum LDH prospectively collected within 3 years before diagnosis. Site-specific analysis was performed for major cancers. Analysis was repeated by different lag times between LDH measurements and diagnosis.

Results

At the end of follow-up, 5799 participants were deceased. Hazard ratios (HRs) and 95% confidence interva

SUBMITTER: Wulaningsih W 

PROVIDER: S-EPMC4815785 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature