Impact of alcohol drinking on gastric cancer development according to Helicobacter pylori infection status.

ABSTRACT:

Background

Helicobacter pylori are major carcinogen of gastric cancer, but the associations among gastric cancer, H. pylori infection status, and alcohol consumption are not fully described. This study aimed to clarify how H. pylori infection status affects the association between alcohol consumption and gastric cancer risk.

Methods

We selected 949 case-cohort participants from the 18,863 Korean Multi-center Cancer Cohort (KMCC) populations. Gastric cancer incidence inside and outside of the subcohort were 12 and 254 cases, respectively. Seropositivities for CagA, VacA, and H. pylori infection were determined by performing immunoblot assays. Weighted Cox regression models were used to calculate hazard ratios and 95% confidence intervals (CIs).

Results

Relative to non-

SUBMITTER: Ma SH 

PROVIDER: S-EPMC4815794 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature