Pin1 facilitates NF-κB activation and promotes tumour progression in human hepatocellular carcinoma.

ABSTRACT:

Background

NF-κB promotes HCC progression; however, therapies targeting NF-κB are not used due to severe adverse reactions. Pin1 is reported to induce tumour progression in vitro. However, the role of Pin1 in HCC is unclear. Moreover, little is known about the mechanism of Pin1-mediated NF-κB activation.

Methods

Fresh surgical specimens were collected from 144 HCC patients. Pin1 and NF-κB-p65 expression was evaluated by immunohistochemistry and western blotting. NF-κB activation was assessed by EMSA.

Results

Pin1 was increased in HCC compared to adjacent liver tissue. The multivariate analysis revealed that high Pin1 expression was an independent factor for poor prognosis. In HCC with high Pin1 expression, tumour size was larger and portal vein invasion was increased.

SUBMITTER: Shinoda K 

PROVIDER: S-EPMC4815797 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature