Loss of CDH1 (E-cadherin) expression is associated with infiltrative tumour growth and lymph node metastasis.

ABSTRACT:

Background

Loss of CDH1 (E-cadherin) expression in cancer cells may promote cell migration and invasion. Therefore, we hypothesised that loss of CDH1 expression in colorectal carcinoma might be associated with aggressive features and clinical outcome.

Methods

Utilising molecular pathological epidemiology database of 689 rectal and colon cancer cases in the Nurses' Health Study and the Health Professionals Follow-up Study, we assessed tumour CDH1 expression by immunohistochemistry. Multivariate logistic regression analysis was conducted to assess association of CDH1 loss with tumour growth pattern (expansile-intermediate vs infiltrative) and lymph node metastasis and distant metastasis, controlling for potential confounders including microsatellite instability, CpG island met

SUBMITTER: Kim SA 

PROVIDER: S-EPMC4815802 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature