Identification of the best complete blood count-based predictors for bladder cancer outcomes in patients undergoing radical cystectomy.

ABSTRACT:

Background

We sought to determine which parsimonious combination of complete blood count (CBC)-based biomarkers most efficiently predicts oncologic outcomes in patients undergoing radical cystectomy (RC) for bladder cancer (BC).

Methods

Using our institutional RC database (1992-2012), nine CBC-based markers (including both absolute cell counts and ratios) were evaluated based on pre-treatment measurements. The outcome measures were recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS). Time-dependent receiver-operating characteristics curves were used to characterise each biomarker. The CBC-based biomarkers, along with several clinical predictors, were then considered for inclusion in predictive multivariable Cox models based on the Akaike

SUBMITTER: Bhindi B 

PROVIDER: S-EPMC4815810 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature