Interplay between cadherins and α2β1 integrin differentially regulates melanoma cell invasion.

ABSTRACT:

Background

Malignant transformation of melanocytes frequently coincides with an alteration in the expression of cell-cell adhesion molecules (cadherins) and cell-extracellular matrix proteins (integrins). How these two adhesion systems interplay to impact on cell invasion remains to be described in melanoma.

Methods

Cell adhesion networks were localised by immunofluorescence in human primary cutaneous melanoma, metastatic melanoma in the lymph nodes, and melanoma cell lines. The role of these cell adhesion networks was assessed both in vivo, by analysing their impact on tumour growth in mice, and in vitro, with the use of functional tests including cell aggregation and cell migration.

Results

We found that α2β1 integrin associates with both E-cadherin and N-cadherin t

SUBMITTER: Siret C 

PROVIDER: S-EPMC4815890 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature