Stenting and medical therapy for atherosclerotic renal-artery stenosis.

ABSTRACT:

Background

Atherosclerotic renal-artery stenosis is a common problem in the elderly. Despite two randomized trials that did not show a benefit of renal-artery stenting with respect to kidney function, the usefulness of stenting for the prevention of major adverse renal and cardiovascular events is uncertain.

Methods

We randomly assigned 947 participants who had atherosclerotic renal-artery stenosis and either systolic hypertension while taking two or more antihypertensive drugs or chronic kidney disease to medical therapy plus renal-artery stenting or medical therapy alone. Participants were followed for the occurrence of adverse cardiovascular and renal events (a composite end point of death from cardiovascular or renal causes, myocardial infarction, stroke, hospitalization

SUBMITTER: Cooper CJ 

PROVIDER: S-EPMC4815927 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature