Genetic and Non-genetic Factors Associated With Constipation in Cancer Patients Receiving Opioids.

ABSTRACT:

Objectives

To examine whether the inter-individual variation in constipation among patients receiving opioids for cancer pain is associated with genetic or non-genetic factors.

Methods

Cancer patients receiving opioids were included from 17 centers in 11 European countries. Intensity of constipation was reported by 1,568 patients on a four-point categorical scale. Non-genetic factors were included as covariates in stratified regression analyses on the association between constipation and 75 single-nucleotide polymorphisms (SNPs) within 15 candidate genes related to opioid- or constipation-signaling pathways (HTR3E, HTR4, HTR2A, TPH1, ADRA2A, CHRM3, TACR1, CCKAR, KIT, ARRB2, GHRL, ABCB1, COMT, OPRM1, and OPRD1).

Results

The non-genetic factors significantly associated

SUBMITTER: Laugsand EA 

PROVIDER: S-EPMC4816247 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature