Influence of Proton-Pump Inhibitors on the Luminal Microbiota in the Gastrointestinal Tract.

ABSTRACT:

Objectives

The objective of this study was to investigate comparatively the influence of proton-pump inhibitors (PPI) administration on three bacterial communities in the oral cavity, stomach, and colon along the alimentary tract.

Methods

Forty-five subjects including 18 patients taking PPI were enrolled. Stimulated saliva, gastric fluid (GF), and feces were obtained from each subject for the microbiota analysis through bacterial 16S rRNA gene profiling using the pyrosequencing method.

Results

The species richness (alpha diversity) was similar among these three microbiota, whereas the interindividual diversity (beta diversity) was much higher in the fecal microbiota compared with that in the others. The UniFrac analysis indicated that the salivary and GF microbiota we

SUBMITTER: Tsuda A 

PROVIDER: S-EPMC4816248 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature