Quantitative Modeling of the Alternative Pathway of the Complement System.

ABSTRACT: The complement system is an integral part of innate immunity that detects and eliminates invading pathogens through a cascade of reactions. The destructive effects of the complement activation on host cells are inhibited through versatile regulators that are present in plasma and bound to membranes. Impairment in the capacity of these regulators to function in the proper manner results in autoimmune diseases. To better understand the delicate balance between complement activation and regulation, we have developed a comprehensive quantitative model of the alternative pathway. Our model incorporates a system of ordinary differential equations that describes the dynamics of the four steps of the alternative pathway under physiological conditions: (i) initiation (fluid phase), (ii) amplificati

SUBMITTER: Zewde N 

PROVIDER: S-EPMC4816337 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature