AT1 receptor blocker losartan protects against mechanical ventilation-induced diaphragmatic dysfunction.

ABSTRACT: Mechanical ventilation is a life-saving intervention for patients in respiratory failure. Unfortunately, prolonged ventilator support results in diaphragmatic atrophy and contractile dysfunction leading to diaphragm weakness, which is predicted to contribute to problems in weaning patients from the ventilator. While it is established that ventilator-induced oxidative stress is required for the development of ventilator-induced diaphragm weakness, the signaling pathway(s) that trigger oxidant production remain unknown. However, recent evidence reveals that increased plasma levels of angiotensin II (ANG II) result in oxidative stress and atrophy in limb skeletal muscles. Using a well-established animal model of mechanical ventilation, we tested the hypothesis that increased circulating level

SUBMITTER: Kwon OS 

PROVIDER: S-EPMC4816409 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature