Clinical MRSA isolates from skin and soft tissue infections show increased in vitro production of phenol soluble modulins.

ABSTRACT:

Background

Phenol-soluble modulins (PSMs) are amphipathic, pro-inflammatory proteins secreted by most Staphylococcus aureus isolates. This study tested the hypothesis that in vitro PSM production levels are associated with specific clinical phenotypes.

Methods

177 methicillin-resistant S. aureus (MRSA) isolates from infective endocarditis (IE), skin and soft tissue infection (SSTI), and hospital-acquired/ventilator-associated pneumonia (HAP) were matched by geographic origin, then genotyped using spa-typing. In vitro PSM production was measured by high performance liquid chromatography/mass spectrometry. Statistical analysis was performed using Chi-squared or Kruskal-Wallis tests as appropriate.

Results

Spa type 1 was significantly more common in SSTI isolates (62.7%

SUBMITTER: Berlon NR 

PROVIDER: S-EPMC4816458 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature