Subcellular Behaviour Evaluation of Nanopharmaceuticals with Aggregation-Induced Emission Molecules.

ABSTRACT: Nanopharmaceuticals possess a myriad of advantages for disease treatment, not only in delivering therapeutic agents, but also in deciphering their innate intracellular or subcellular behaviours, providing detailed diagnostic and prognostic information, quantifying treatment efficacy and designing better therapeutics. To evaluate the subcellular behaviour of nanopharmaceuticals, colourful fluorescence is the most potential technique, because it is capable of painting the subcellular detail in three dimensions with high resolution. Furthermore, the fluorescence is switchable, and thus the subcellular details can be lightened specifically without the undesirable background. However, most nanopharmaceuticals lack a fluorescent report group, and its introduction requires extra steps. Moreover,

SUBMITTER: Xue X 

PROVIDER: S-EPMC4816494 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature